For more than three decades Vincent Di Fate has held an international reputation as one of the world's leading artistic visionaries of the future. People Magazine has said that he is "One of the top illustrators of science fiction, Di Fate is not all hard-edge and airbrush slickness. His works are always paintings — a bit of his brushwork shows — and they are all the better because of it." And Omni Magazine has made the observation that "Moody and powerful, the paintings of Vincent Di Fate depict mechanical marvels and far frontiers of a future technocracy built on complicated machinery and human resourcefulness. Di Fate is something of a grand old man in the highly specialized field of technological space art. Stirring images of far-flung environments have been his trademark." In his prolific career, he has produced art of science fiction, astronomical and aerospace subjects for such clients as IBM, The Reader's Digest, The National Geographic Society, and the National Aeronautics and Space Administration.

Di Fate has received many awards for his paintings, including the Frank R. Paul Award for Outstanding Achievement in Science Fiction Illustration (1978), the Hugo Award (Science Fiction Achievement Award) for Best Professional Artist (1979), the Skylark Award for Imaginative Fiction (1987), the Lensman Award for Lifetime Contribution to the Science Fiction Field (1990), and the Chesley Award from the Association of Science Fiction/Fantasy Artists for Lifetime Artistic Achievement (1998). He was also Guest of Honor at the 50th World Science Fiction Convention in Orlando, Florida in 1992 and has been an honored guest at numerous regional SF and fantasy conventions throughout the U.S. since the late 1960s.

The artist has had his paintings exhibited in numerous group and one-man shows at museums and galleries throughout North America, Europe, Asia and Japan. These include important solo exhibitions at the Reading Museum in Pennsylvania, the Museum of Science and Natural History in St. Louis, Missouri, and at the Hayden Planetarium (American Museum of Natural History) in New York City. His work is included in the collections of the National Air and Space Museum (Smithsonian Institution) and the U. S. Air Force Art Collection in Washington, D. C., the Society of Illustrators in New York City, the National Aeronautics and Space Administration at Cape Canaveral, Florida, the New Britain Museum of American Art in Connecticut, and in the University of Kansasā Center for Science Fiction Studies at Lawrence. He was commissioned by NASA in 1985 to create the official painting of the International Space Station currently being assembled in Earth orbit. That painting, completed in 1987, is now on display at the Kennedy Space Center at Cape Canaveral. His art is also present in many corporate collections.

Di Fate has published two major books, Di Fate's Catalog of Science Fiction Hardware (Workman Publishing Co, 1980) and Infinite Worlds: The Fantastic Visions of Science Fiction Art (Penguin Studio Books, 1997). The award winning Infinite Worlds is the first comprehensive history of science fiction art in America. In addition, Di Fate has lectured extensively about the methods, meaning and history of his craft and has been a consultant for MCA/Universal, 20th Century Fox and MGM/United Artists. He is an Adjunct Professor at the Fashion Institute of Technology (State University of New York) in New York City, where he teaches courses in the history of illustration and in science fiction and fantasy art. He served two terms as president of the Society of Illustrators (1995-1997), an organization of which he is a Life Member, chaired the Permanent Collection Committee for the Museum of America Illustration (SI) from 1985 to 1995, and has served on the Illustration Committee for the Sanford Low Collection of the New Britain Museum of American Art since 1993. He is also a founding member and a past president of the Association of Science Fiction/Fantasy Artists.